HL-60（人白血病肿瘤细胞）
CBP60517
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| I. General information | |
| Synonyms: | HL-60 |
| Background: | HL-60 is a promyelocytic cell line derived by S.J. Collins, et al. Peripheral blood leukocytes were obtained by leukopheresis from a 36-year-old Caucasian female with acute promyelocytic leukemia. |
| Species: | Homo sapiens, human |
| Tissue: | peripheral blood |
| Disease: | acute monocytic leukemia |
| Gender: | Caucasian,female, 36 years |
| Morphology: | myeloblastic |
| Growth Mode: | suspension |
| DNA Profile: | D5S818: 12 D13S317: 8,11 D7S820: 11,12 D16S539: 11 vWA: 16 THO1: 7,8 Amelogenin: X TPOX: 8,11 CSF1PO: 13,14 Cobioer’s Cell Line Authentication Service |
| Culture Medium: |
RPMI-1640+20%FBS HL-60完全培养基，# CBP60517M |
| Cryopreservation medium: | 90%FBS+10%DMSO |
| Receptor Expression: | complement, expressed,Ref Fc, expressed ,Ref |
| Oncogene: | myc + |
| Genes Expressed: | tumor necrosis factor (TNF), also known as tumor necrosis factor alpha (TNF-alpha, TNF alpha), after stimulation with phorbol myristic acid,myc + |
| Cellular Products: | tumor necrosis factor (TNF), also known as tumor necrosis factor alpha (TNF-alpha, TNF alpha), after stimulation with phorbol myristic acid |
| Tumor Formation: | Yes, in nude mice (subcutaneous myeloid tumors),Yes, in semi-solid media |
| Comments: | HL-60 cells spontaneously differentiate and differentiation can be stimulated by butyrate, hypoxanthine, phorbol myristic acid (PMA, TPA), dimethylsulfoxide (DMSO, 1% to 1.5%), actinomycin D, and retinoic acid. The cells exhibit phagocytic activity and responsiveness to chemotactic stimuli. The line is positive for myc oncogene expression. For more information, please contact Cobioer (4008-750-250). |
