Su-DHL-6 (细胞会贴壁)（人B细胞淋巴瘤）
CBP60993
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| I. General information | |
| Synonyms: | Su-DHL-6 |
| Background: | The DHL cell lines were successfully established in continuous suspension culture from 10 patients with a histopathological diagnosis of diffuse histiocytic lymphoma (DHL). |
| Species: | Homo sapiens, human |
| Tissue: | peritoneal effusion; derived from metastatic site: peritoneal cavity |
| Disease: | large cell lymphoma; diffuse mixed histiocytic and lymphocytic lymphoma; follicular B cell lymphoma |
| Gender: | male, Caucasian |
| Morphology: | lymphoblast-like |
| Growth Mode: | suspension |
| Doubling Time: | approximately 29 hours |
| DNA Profile: | D5S818: 12 D13S317: 12,14 D7S820: 10 D16S539: 11,12 vWA: 14,17 THO1: 6,9.3 TPOX: 11,12 CSF1PO: 10 Amelogenin: X Cobioer’s Cell Line Authentication Service |
| Culture Medium: |
RPMI-1640+10%FBS+0.05 mM 2-mercaptoethanol Su-DHL-6完全培养基，# CBP60993M |
| Cryopreservation medium: | 90%FBS+10%DMSO |
| Genes Expressed: | monoclonal cytoplasmic immunoglobulin: IgM; lambda light chain |
| Comments: | All of the DHL cell lines were negative for the presence of Epstein-Barr virus (EBV) genomes. SU-DHL-6 possesses a t(14;18)(q32;q21) translocation and demonstrates an unexpected recombination within its heavy chain gene locus that may be the interchromosomal breakpoint. In SU-DHL-6, the t(14;18) translocation juxtaposes a truncated bcl-2 gene with J6 in a tail-to-head configuration. The deregulated expression of the altered bcl-2 gene may play a critical role in the disordered growth and differentiation of follicular B cell lymphoma. For more information, please contact Cobioer (4008-750-250). |
