TM4（小鼠正常睾丸sertoli细胞）
CBP60969
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| I. General information | |
| Synonyms: | TM4 |
| Species: | Mus musculus, mouse |
| Tissue: | testis |
| Gender: | male, 11 to 13 days |
| Morphology: | epithelial |
| Growth Mode: | adherent |
| Culture Medium: |
DMEM:F12+5%HS+2.5%FBS TM4完全培养基，# CBP60969M |
| Cryopreservation medium: | 90%FBS+10%DMSO |
| Antigen Expression: | H-Y antigen; Mus musculus, expressed |
| Receptor Expression: | follicle stimulating hormone (FSH), expressed androgen receptor, expressed progesterone receptor, expressed |
| Genes Expressed: | retinol binding protein, tissue plasminogen activator, transferrin |
| Tumor Formation: | No, The cells were not tumorigenic in immunosuppressed mice, but did form colonies in semisolid medium. |
| Comments: | The TM4 cell line is reported to respond to FSH with an increase in cAMP production, but to not respond to luteinizing hormone (LH). The FSH responsiveness is much reduced compared to primary sertoli cell cultures. Constitutive plasminogen activator production is reported to be low, but is stimulated by FSH and, to a greater extent, by retinoic acid. Tested and found negative for ectromelia virus (mousepox). For more information, please contact Cobioer (4008-750-250). |
