C-33 A（人子宫颈癌细胞）
CBP60707
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| I. General information | |
| Synonyms: | C-33 A |
| Species: | Homo sapiens, human |
| Tissue: | cervix |
| Disease: | carcinoma |
| Gender: | Caucasian,Female,66 years adult |
| Morphology: | epithelial |
| Growth Mode: | adherent |
| DNA Profile: | Amelogenin: X CSF1PO: 12 D13S317: 13 D16S539: 13,14 D5S818: 11,12 D7S820: 10 THO1: 7,8 TPOX: 9 vWA: 18,20 Cobioer’s Cell Line Authentication Service |
| Culture Medium: |
MEM + 10% FBS+ 1% Non Essential Amino Acids (NEAA) + 1mM Sodium Pyruvate (NaP) C-33 A完全培养基，# CBP60707M |
| Cryopreservation medium: | 90%FBS+10%DMSO |
| Oncogene: | p53 +; pRB + |
| Genes Expressed: | p53 +; pRB + |
| Tumor Formation: | Yes, in nude mice; forms undifferentiated carcinoma |
| Comments: | The line exhibited a hypodiploid karyotype initially, and an epithelial morphology.Karyological instability was observed with continued passage. The retinoblastoma protein (pRB) is present but abnormal in size.Expression of p53 is elevated, and there is a point mutation at codon 273 resulting in a Arg -> Cys substitution. he cells are negative for human papillomavirus DNA and RNA. The C-33 A cell line is one of a series of lines (see also ATCC CRL-1594 and ATCC CRL-1595) derived by N. Auersperg from cervical cancer biopsies. For more information, please contact Cobioer (4008-750-250). |
