c-Kit D816H/BaF3
CBP73282
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| I. Introduction | |
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Cell Line Name： |
c-Kit D816H/BaF3 |
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Host Cell: |
Ba/F3 |
| Stability: | 16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
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Application: |
Anti-proliferation assay and PD assay |
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Freeze Medium: |
90% FBS+10% DMSO |
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Complete Culture Medium: |
RPMI-1640+10%FBS |
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Mycoplasma Status: |
Negative |
| II. Background | |
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KIT D816H lies within the tyrosine kinase domain region 2 (exon 17) of the Kit protein (PMID: 19164557). D816H results in increased kinase activity, constitutive Kit phosphorylation, activation of Stat3 signaling, and transformation of cultured cells (PMID: 10362788, PMID: 11494148), and confers resistance to some Kit inhibitors (PMID: 25239608). |
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| III. Representative Data | |
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1. WB of c-Kit D816H/BaF3
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2. Sanger of c-Kit D816H/BaF3
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3. Anti-proliferation assay
Figure 3. CTG Proliferation Assay of BaF3 C-KlT D816H. |
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