hTACI Effector Reporter Cell
CBP74219
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| I. Background | |
| TACI regulates immune cell homeostasis, differentiation and function and is embedded in a complex network of cytokines, TNFSF ligands, microbial danger signals and its cognate receptors. TACI primarily serves as a receptor for BAFF (B cell activating factor) and APRIL (A proliferation inducing ligand) .TACI shares binding of BAFF and APRIL with its cognate receptor BCMA whereas BAFF-R can only bind BAFF. | |
| II.Introduction | |
| Expressed gene: | hTACI |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10%DMSO |
| Culture Medium: | 1640+10%FBS+800ug/ml hygromycin+1ug/ml puromycin |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| Application(s): | Functional(Report Gene) Assay |
| III. Representative Data | |
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Figure 1. Dose response of Ligands in hTACI Effector Reporter Cells (C32). |
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Figure 2. Inhibition of Human BAFF¬induced Reporter Activity by BAFF Neutralization in hTACI Effector Reporter Cells(C32). |
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Figure 3.Inhibition of Human APRlL-induced Reporter Activity by APRlL Neutralization in hTACI Effector Reporter Cells(C32). |
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