NPM1(E4)-ALK(E20) Fusion
CBP20032R
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| Introduction | |
| Format | RNA |
| Description | NPM1-ALK fusion protein p80 is derived from the fusion of the N-terminal oligomerization domain of NPM1 (1–110 aa) and the C-terminal tyrosine kinase domain of ALK (1058–1620 aa). In these malignancies, the homo-dimerization of NPM1-ALK leads the constitutive activation of a fusion kinase in a ligand-independent manner. The persistently active tyrosine kinase NPM1-ALK triggers multiple intracellular downstream signaling pathways including AKT, ERK1/2, and STAT3, which results in proliferation and survival of ALCL cells. |
| Technical Data | |
| Left Gene | NPM1 |
| Left Breakpoint | chr5:170818803:+ (hg19) |
| Transcript | NM_002520.7 |
| Right Gene | ALK |
| Right Breakpoint | chr2:29446394:- (hg19) |
| Transcript | NM_004304.5 |
| Cosmic ID | COSF198 |
| Buffer | RNase-free H2O |
| Product Information | |
| Intended Use | Research Use Only |
| Unit Size | 1ug |
| Concentration | Download for COA |
| Purity | Download for COA |
| RNA electrophoresis | Download for COA |
| Sanger sequencing |  |
| Storage | -80℃ |
| Expiry | 12 months from the date of manufacture |
