TP53 p.C176F Reference Standard
CBP10150
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| Introduction | |
| Format | Genomic DNA |
| Description | TP53 C176F lies within a zinc binding residue in the DNA-binding region of the Tp53 protein (UniProt.org). C176F is predicted to confer a loss of function to the Tp53 protein, as demonstrated by the inability to induce CDKN1A (p21) transcription in cell culture (PMID: 22090360). |
| Technical Data | |
| DNA Change: | c.527G>T |
| AA Change | p.C176F |
| Mutation type | Substitution - Missense |
| Zygosity | Heterozygous |
| Allelic Frequency | 33.33% |
| Transcript | ENST00000269305 |
| Cosmic ID | COSM10645 |
| Chr position(GRCh37) | chr17:7578403 |
| Buffer: | Tris-EDTA |
| Product Information | |
| Intended Use | Research Use Only |
| Unit Size | 1ug |
| Concentration | Download for COA |
| Purofication | Download for COA |
| DNA electrophoresis | Download for COA |
| Sanger sequencing | Download for COA |
| Storage | 4℃ |
| Expiry | 36 months from the date of manufacture |
