BRAF p.G464V Reference Standard
CBP10695
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| Introduction | |
| Format | Genomic DNA |
| Description | BRAF G464V (also reported as G463V) lies within the protein kinase domain of the Braf protein (UniProt.org). G464V results in increased Braf kinase activity and increased downstream Mek and Erk activation, and in one of two cell lines, increased cell proliferation and viability compared to wild-type Braf in culture. |
| Technical Data | |
| DNA Change | c.1391G>T |
| AA Change | p.G464V |
| Mutation type | Substitution - Missense |
| Zygosity | Heterozygous |
| Allelic Frequency | 50% |
| Transcript | NM_004333.6 |
| Cosmic ID | COSM450 |
| Chr position(GRCh37) | chr7:140481417 |
| Buffer | Tris-EDTA |
| Product Information | |
| Intended Use | Research Use Only |
| Unit Size | 1ug |
| Concentration | Download for COA |
| Purofication | Download for COA |
| DNA electrophoresis | Download for COA |
| Sanger sequencing |  |
| Storage | 4℃ |
| Expiry | 36 months from the date of manufacture |
